In medieval England, devout individuals—women in particular—self-isolated professionally, living confined to little rooms attached to parish churches. Although discomfort constituted the heart of this vocation, guides written for these anchorites also envisage enclosure as bringing risks to physical and mental health. These risks map onto acedia and sloth, two overlapping sins against which these texts caution. I argue that the anchoritic cell as metaphor and matter mediates the anchoritic endeavour of generating acedia and sloth and overcoming them. Twinning a literary approach with a feedback model from cognitive behavioural therapy, my discussion juxtaposes two texts addressing female anchorites, the thirteenth-century Ancrene Wisse, and The Form of Living by Richard Rolle (1300–1349) with two texts by female anchorites, A Revelation of Purgatory by an anonymous fifteenth-century anchorite and A Revelation of Love by Julian of Norwich (ca. 1343–ca. 1416). It probes whether, in these texts, the cell shifts the dynamics of the feedback loop from self-reinforcing to self-stabilizing or maintains these self-reinforcing dynamics. This discussion concludes by examining the stakes involved in the texts’ commitment to the cell’s ascetic materiality. Charting parallels to the home during COVID-19 lockdowns and historicizing the gendered physical and mental effects of (self-)isolation in narrow spaces, this analysis of medieval enclosure resonates with modern concerns about how confined spaces materialize power.